- Using advanced vacuum dynamic reflux extraction technology, extract the formula drugs under 0.06-0.08 Mpa vacuum and 60-70°C low temperature, maximizing the retention of the active ingredients in traditional Chinese medicine. There are more than 28 active ingredients in the solution: besides Baicalin, Forsythiaside, Forsythin, and Chlorogenic acid, there are other active ingredients such as saponin, flavone, iridoid glycoside, β-sitosterol, lignin and triterpene.
- Using a 16300r/min high-speed tube centrifuge to remove impurities instead of the traditional precipitation method, not only shortens the process and extraction time but also higher the purity of the extract, the effect is remarkable.
- Using special processing technology to increase the solubility of various components of the drug in water, and making the original incompatible substances mixed to obtain a stable solution at high concentrations, long time placing without delamination, no precipitation. Note: National Research Center for Veterinary Medicine will carry out a strict inspection of each batch of products, so as to meet the content standards. Among them, Scutellaria contains Baicalin ≥ 13mg/ml; Lonicera contains Chlorogenic acid ≥ 0.8mg/ml; Forsythia contains Forsythin ≥ 0.5mg/ml.
The following is the determination of the content of 3 batches of samples produced in Sep 2011:
1、The sampling results showed the contents of three major substances in the three batched of ShuangHuangLian oral solution are all higher than the content standards stipulated in the Pharmacopoeia (Baicalin ≥10mg/ml, Chlorogenic acid≥0.6mg/ml, Forsythin≥0.3mg/ml).
2、SHL is a broad-spectrum anti-virus medicine, with a significant effect on Influenza virus, Adenovirus, Pneumonia, Infectious bursal disease virus, Infectious bronchitis virus and Infectious laryngotracheitis virus.
3、Antibacterial effect: The study found that chlorogenic acid in Lonicera, saponin, Baicalin in Scutellaria, Baicalein and other flavonoids, triterpenoid saponins in Forsythia; all have obvious antibacterial and bactericidal effects. In vitro antibacterial test found that ShuangHuangLian formulation has strong inhibitory effect on Staphylococus aureus, Hemolytic streptococcus, Salmonella typhi, E.coli, Proteus, Pseudomonas aeruginosa, Shigella dysenteriae and Meningococcus.
4、Antipyretic and analgesic effects: SHL can significantly inhibit swelling and increased vascular permeability, caused by inflammatory mediators; also has an obvious antipyretic effect, and shows dose response.
5、Immunomodulatory effects: SHL is a versatile immune enhancer.Could antagonize hydrocortisone-induced immune suppression in mice. It can also promote the formulation of the hemolysin, and enhance immune function in mice. In vivo experiments showed that low dose baicalin had regulatory functions for the mouse peritoneal macrophages, which could significantly increase the content of lysozyme phagocytosed by macrophages.
Comparison of antibacterial activities of ShuangHuangLian oral solution by different manufacturers.
|Strains||Sample||Manufacturer||Inhibitory zone diameter|
|10 times||20 times|
|E.coli||Sample 1||Rainbow||15.22 mm||14.18 mm|
|Sample 2||Market product 1||9.42 mm||*|
|Sample 3||Market product 2||*||*|
|Sample 4||Market product 3||*||*|
|Staphylococcus aureus||Sample 1||Rainbow||23.64 mm||21.42 mm|
|Sample 2||Market product 1||20.88 mm||18.62 mm|
|Sample 3||Market product 2||*||—|
|Sample 4||Market product 3||*||*|
|Streptococcus||Sample 1||Rainbow||15.36 mm||13.80 mm|
|Sample 2||Market product 1||11.61 mm||*|
|Sample 3||Market product 2||—||—|
|Sample 4||Market product 3||—||*|
Note: “*” ” / ” means no antibacterial activity;
“*” means there is sterility in the Oxford cup, the inhibition zone size is the same with the cup diameter.
” / ” means bacteria still grow under the pressure of high concentrations of drugs in the Oxford cup.
Test results showed: compared with three other SHL products on market, the one produced by Rainbow Feeding using advanced technology has stronger antibacterial activity on E.coli, Staphylococcus aureus, and Streptococcus, especially on Staphylococcus aureus.
heat-clearing and detoxifying, it was clinically applied to treat hyperpyrexia coma, close eyes and be in a daze, comb purple, snoring, coughing, difficult breathing, swollen head, squama on the legs bleed, yellow-green and white feces, laying rate drop, Pneumonia.
Usage and dosage
1ml/1L water, 1 water mixed the 1ML SHL, a free drink for poultry or Twice a day, used in conjunction with 3 -5 days.